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Use caution when prescribing contrave to patients with an elevated risk of seizure, including history of head trauma or prior seizure, severe stroke, arteriovenous malformation, central nervous system tumor or infection, or metabolic disorders eg, hypoglycemia, hyponatremia, severe hepatic impairment, and hypoxia ; excessive use of alcohol or sedatives, addiction to cocaine or stimulants, or withdrawal from sedatives; patients with diabetes treated with insulin and or oral diabetic medications sulfonylureas and meglitinides that may cause hypoglycemia; concomitant administration of medications that may lower the seizure threshold, including other bupropion products, antipsychotics, tricyclic antidepressants, theophylline, and systemic steroids.
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